By K. Sato
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Extra resources for Embryogenesis
With rare exception, none of the twin pairs included in those calculations were actually diagnosed for zygosity, let alone soundly diagnosed. The MZ excesses of the malformations considered there have in general been decided by sorting into same-sex vs opposite-sex twin pairs, under the assumption that the boy-girl pairs are in all ways developmentally representative of all dizygotic twins, and that the apparent concentration of difficulties in the like-sex pairs is due entirely to their concentration among the monozygotic members of the like-sex pairs.
Betancur P, Bronner-Fraser M, Sauka-Spengler T. (2010) Assembling neural crest regulatory circuits into a gene regulatory network. Ann Rev Cell Dev Biol 26:581-603.
22 Embryogenesis Whether the twins thus initiated are monozygotic or dizygotic is a genetic distinction, not a cellular one. Two zygotes never had to mean two cells. Cells within an embryogenic cell mass that will generate monozygotic twins all have copies of one nuclear genome. [Keep in mind the occasional occurrence of post-zygotic mutations that may establish a second genetically distinct cell line – even a second embryo. ] Dizygotic twins are built from cells with two different nuclear genomes, most likely different in every chromosome.
Embryogenesis by K. Sato