Download Drug-Induced Liver Disease by Neil Kaplowitz, Laurie D. DeLeve PDF

By Neil Kaplowitz, Laurie D. DeLeve

ISBN-10: 0849398967

ISBN-13: 9780849398964

Epidemiological stories have came upon that medications are actually the commonest reason for liver failure within the usa, and the earlier decade has noticeable an explosion of recent info in regards to the immunology, toxicology, and pharmacology of drug-induced liver disorder. This expertly written moment variation provides an in-depth dialogue of the hot advancements in drug-induced hepatotoxicity, protecting mechanisms, histopathology, administration, possibility elements, and styles of drug and toxin-induced liver affliction.

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45. Tirona RG, Leake BF, Podust LM, et al. Identification of amino acids in rat pregnane X receptor that determine species-specific activation. Mol Pharmacol 2004; 65(1):36–44. 46. Liebler DC, Guengerich FP. Elucidating mechanisms of drug-induced toxicity. Nat Rev Drug Discov 2005; 4(5):410–20. 47. Kalgutkar AS, Gardner I, Obach RS, et al. A comprehensive listing of bioactivation pathways of organic functional groups. Curr Drug Metab 2005; 6(3):161–225. 48. Uetrecht JP. New concepts in immunology relevant to idiosyncratic drug reactions: the “danger hypothesis” and innate immune system.

Mueller GC, Miller JA. The metabolism of 4-dimethylaminoazobenzene by rat liver homogenates. J Biol Chem 1948; 176(11):535–44. 4. Jollow DJ, Mitchell JR, Potter WZ, et al. Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J Pharmacol Exp Ther 1973; 187(1):195–202. 5. Zampaglione N, Jollow DJ, Mitchell JR, et al. Role of detoxifying enzymes in bromobenzene-induced liver necrosis. J Pharmacol Exp Ther 1973; 187(1):218–27. 6. Basu AK, Essigmann JM. Site-specifically modified oligodeoxynucleotides as probes for the structural and biological effects of DNA-damaging agents.

Thus, this context has some similarity to the second one (Table 2), except that an immune system component is usually not invoked. , that protein acts as a “master switch” for the cell. However, a more accepted current view is that cells have very complex networks and that disruption of those signaling pathways (46) or any of several of the systems involved in energy production (7) may lead to toxicity, with effects being cell and tissue specific (see also chaps. 4 and 5). 1/104 patients), a serious problem, and not understood (by definition).

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Drug-Induced Liver Disease by Neil Kaplowitz, Laurie D. DeLeve


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