By M. Wilkinson (auth.), Hans-Christoph Diener MD, Marcia Wilkinson MA, DM, FRCP (eds.)
M. WILKINSON sufferers with common or day-by-day complications pose a truly tough challenge for the medical professional who has to regard them, relatively as many sufferers imagine that there may be a medication or medications which provide them quick aid. within the look for the compound which might meet this very average hope, many medicines were synthetic and the temptation for the healthcare professional is both to extend the dose of a drug which looks, at any price, in part potent, or so as to add a number of medications to these which the sufferer is already taking. even supposing there were a few references to the risks of overdosage of gear for migraine some time past, it was once no longer till quite lately that it used to be well-known that medicines given for the relaxation of headache, if taken injudiciously, could themselves reason headache. the 1st medications to be implicated during this approach have been ergotamine and phenazone. on the subject of ergotamine tartrate, the hazards of ergotism have been popular as this was once a sickness which were identified and written approximately for a few years. within the remedy of headache, absolutely blown ergotism is uncommon and in recent times has often been because of self-medication in doses a lot more than these prescribed even though there are a couple of recorded instances the place poisonous quantities were given.
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Additional info for Drug-Induced Headache
Thus, 29 of the patients initially suffered from common migraine, five from tension headache, one each from post-traumatic headache, hypotonia, and depression. In two patients no distinct diagnosis of primary headache was possible. Statistical Analysis We calculated the mean and median dosages of intake per headache day and per month for each single drug. For group comparisons we used a median as the basis since the values within the groups were not normally distributed. For group comparisons we therefore used nonparametric tests (Mann-Whitney Wilcoxon).
Br J Clin Pharmacol22:8187 Dichgans J, Diener HC, Gerber WD, Verspohl EJ, Kukiolka H, Kluck M (1984) Analgetikainduzierter Dauerkopfschmerz. Dtsch Med Wochenschr 109:369-373 Gibson T, Zaphiropoulos G, Grove J, Widdop B, Berry D (1975) Kinetics of salicylate metabolism. Br J Clin Pharmacol2:233 Henry P, Dartigues JF, Benetier MP, Lucas J, Duplan B, Jogeix M, Orgogozo JM (1985) Ergotamine- and analgesic-induced headaches. In: Rose FC (ed) Migraine. Proc 5th Int Migraine Symp London 1984. Karger, Basel, pp 197-205 Horton BT, Peters GA (1963) Clinical manifestations of excessive use of ergotamine preparations and management of withdrawal effect: report of 52 cases.
Statistical Evaluation The statistical evaluation was performed descriptively. 9 years). The age and sex distribution is shown in Table 1. 4% from combination headache. 6%. As has been reported in the literature, migraine and com- 46 V. Pfaffenrath and U. Niederberger Table 1. 2 8-82 Total bination headache were mostly seen in females and cluster headache in males. There was only a slightly higher frequency of tension headache in women. 2%) with coital headache (Lundberg and Osterman 1974). The small number of patients with trigeminal neuralgia is explained by the fact that these cases are usually referred to our Neurosurgical Outpatient Department for facial pain.
Drug-Induced Headache by M. Wilkinson (auth.), Hans-Christoph Diener MD, Marcia Wilkinson MA, DM, FRCP (eds.)