Download Diag., Scrng, Trtmt of Abdominal, Thoracoabdominal, Thoracic by R. Grundmann PDF

By R. Grundmann

ISBN-10: 9533074663

ISBN-13: 9789533074665

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Additional info for Diag., Scrng, Trtmt of Abdominal, Thoracoabdominal, Thoracic Aortic Aneurysms

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Science 1997;277(5328):959-965 Smulders YM & Blom HJ. The homocysteine controversy. J Inherit Metab Dis 2011;34:93-99 Spark JI, Laws P & Fitridge R. The Incidence of Hyperhomocysteinemia in Vascular Patients. Eur J Vasc Endovasc Surg 2003;26:558-561 Steenge GR, Verhoef P & Katan MB. Betaine Supplementation Lowers Plasma Homocysteine in Healthy Men and Women. J Nutr 2003;133:1291-1295 Strauss E, Waliszewski K, Gabriel M, Zapalski S & Pawlak AL. Increased risk of the abdominal aortic aneurysm in carriers of the MTHFR 677T allele.

Despite this, the observed single base pair change does not change translation and is therefore unlikely to be involved in the pathogenesis of AAA. It does however, raise the possibility that other polymorphisms identified within the TIMP gene (G418C and C177T), maybe linked to AAA formation (Sandford et al, 2007), although this has not been investigated to date. Polymorphisms of both PAF and PAI genes have also been linked to AAA. A 5G allele in position 675 of the PAI-1 gene is associated with reduced transcription and is expressed more frequently in patients with a family history of AAA (Rossaak et al, 2000).

NO contributes to vessel homeostasis by inhibiting vascular smooth muscle contraction and growth, platelet aggregation, and leukocyte adhesion to the endothelium. The resultant over-production of oxidative free radicals has been shown to induce intimal injury, activate elastase and increase calcium deposition (Brunelli et al, 2000). The toxic effects of hyperHcy on the endothelium extend to the prothrombotic environment that is created at several levels. These include increased platelet aggregation, activation of clotting factors V, X and XII, along with depressed activation of protein C and cell surface thrombomodulin and modulation of tissue plasminogen activator binding to its cell surface receptor, annexin II (Perna et al, 2003).

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Diag., Scrng, Trtmt of Abdominal, Thoracoabdominal, Thoracic Aortic Aneurysms by R. Grundmann

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