By Klaus Peter Wilhelm, Hongbo Zhai, Howard I. Maibach
The foundational reference in dermal toxicology, this vintage textual content has been thoroughly revised to convey it modern within the new 8th version, with nearly a 3rd of its chapters being newly extra. The constitution of the textual content has additionally been reorganized to allow more uncomplicated situation of a subject of curiosity. With contributions from top foreign specialists, this keeps the culture of delivering unsurpassed theoretical and useful suggestions for all these engaged on learn facets, on functional medical concerns, and at the regulatory points of publicity to poisonous substances.
This re-creation comprises updates to every bankruptcy and contributions from prime foreign specialists, offers an in-depth precis of study and regulatory functions concerning dermal toxicology and pharmacology, offers many new chapters that describe the newest advances in dermatotoxicology, and addresses quite a few degrees of craftsmanship concerning the improvement and use of dermal publicity information. New chapters contain these on safety terminology, pharmacogenetics and dermatology, ethnic changes in epidermis houses, and the foundations and perform of percutaneous absorption.
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Extra resources for Dermatotoxicology, Eighth Edition
Furthermore, the push for animal-free hazard and risk assessment of chemical skin sensitization fosters the principles of EBT. It has been recognized that this can only be achieved by integrating evidence from a variety of sources that are mapped onto the frame of up-to-date mechanistic understanding (61). To provide a sound basis for further advances in the field, improved knowledge or introduction of new tests, the evidence integration/synthesize has to fulfill several requirements. These requirements of transparency, consistency, and rationality are identical to those of EBT.
However, diagnostic test assessment has developed several approaches to remedy this situation (33), some of which have already been proposed for use in toxicology (34). Especially in this aspect, the movement driving the whole of toxicology to an understanding of the pathways of toxicity, for example, as an, if not the essential concept of the vision of the toxicology of the future (10,35), and DERMATOTOXICOLOGY the concepts of an EBT intertwine. One the one hand, the need of pathway toxicology to minimize or, if possible, eliminate the species differences resulting from the extrapolation from animal model data to humans will reduce the issue of imperfectness of references in test assessment.
Toxicol Sci 2009; 112: 297–302. 9. Hartung T. Evidence-based toxicology - the toolbox of validation for the 21st century? Altern Anim Exp 2010; 27: 253–63. 10. NRC (National Research Council). Toxicity Testing in the 21st Century: A Vision and a Strategy. Washington, DC: National Academy Press, 2007. 11. Sackett DL, Rosenberg WMC, Gray JAM, Haynes RB, Richardson WS. Evidence based medicine: what it is and what it isn’t. BMJ 1996; 312: 71–2. DERMATOTOXICOLOGY 12. Eddy DM. Evidence-based medicine: a unified approach.
Dermatotoxicology, Eighth Edition by Klaus Peter Wilhelm, Hongbo Zhai, Howard I. Maibach