By Werner Kempf
A sound historical past in dermatopathology is vital for the prognosis of either inflammatory dermatoses and cutaneous tumors. This ebook presents an advent to the rules of dermatopathology, aimed basically at dermatologists and pathologists in education, yet necessary for a large audience
Everyone attracted to dermatopathology will benefit from mixed wisdom of four skilled dermatopathologists, uniform constitution procedure focusing on universal diagnoses, logical presentation of scientific and histological positive aspects, huge basically categorized illustrations, clues for differential diagnostic considerations.
All images are in colour, published on fine quality paper, in actual fact categorized and designed to assist each reader become proficient at picking out either styles and particular diagnostic positive aspects rapidly.
A dermatopathology designed for use, not only learn – written by way of practitioners for day-by-day practice.
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Extra resources for Dermatopathology
Spontaneous resolution over weeks to months Histopathology Focal hyperkeratosis Slight acanthosis with widened rete ridges Discrete spongiosis with exocytosis of lymphocytes and occasionally a parakeratotic cap Lymphocytic infiltrates with occasional eosinophils in upper dermis, especially in widened dermal papillae Extravasation of erythrocytes and occasional intraepidermal erythrocytes Differential diagnoses ] Subacute dermatitis Acanthosis, spongiosis, exocytosis of lymphocytes. Superficial lymphocytic perivascular infiltrate, often with eosinophils ] Erythema annulare centrifugum Minimal epidermal changes and superficial lymphocytic perivascular infiltrate, identical to pityriasis rosea.
Inclusions of exudate and neutrophils in cornified layer ] Pustular tinea Exocytosis of neutrophils with pustules but presence of fungal elements in cornified layer with PAS stain ] Impetigo Subcorneal acantholysis with exudate and numerous neutrophils in cornified layer. Clefting with acantholysis mostly beneath cornified layer, producing subcorneal blisters ] Pustular drug eruption Focal discrete spongiosis with subcorneal pustules, occasionally including eosinophils. Usually histologically identical to pustular psoriasis Comment Pustular psoriasis, impetigo and subcorneal pustulosis are often impossible to separate histologically.
Mixed infiltrate rich in eosinophils and edema in upper and mid-dermis Bullous phase Subepidermal blister with separation of entire epidermis. Blister lumen contains eosinophils, neutrophils, and fibrin. In upper dermis mixed infiltrate rich in eosinophils with occasional neutrophils Additional studies . DIF: Linear deposits of IgG and C3 and IgA (40%) at the DEJ. In salt-split skin, IgG antibodies on the roof of blister. Immunohistochemistry: type IV and type VII collagen at base of blister .
Dermatopathology by Werner Kempf