By Kenneth A. Walters
Containing 350 illustrations, tables, and equations and overlaying AAPS/FDA guidance for the experimentation and research of in vivo and in vitro percutaneous absorption, this reference offers finished assurance of the improvement, practise, and alertness of topical and transdermal healing structures. well-known foreign specialists talk about the bioequivalence of dermatological and transdermal dosage kinds. They discover the biochemistry and therapy of dermis illnesses, the constitution and serve as of the outside, hostile dermal responses to drug formulations, mechanisms of drug delivery via barrier membranes, and techniques for measuring and modulating percutaneous permeation.
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Additional info for Dermatological and Transdermal Formulations (Drugs and the Pharmaceutical Sciences)
1996) The use of vibratome sections for the ruthenium tetroxide protocol: a key for optimal visualization of epidermal lipid bilayers of the entire human stratum corneum in transmission electron microscopy. J Microstruct 184:67–70. Pilgram GSK, Engelsma–van Pelt AM, Bouwstra JA, Koerten HK. (1999) Electron diffraction provides new information on human stratum corneum lipid organization studied in relation to depth and temperature. J Invest Dermatol 113:403–409. Fensky DB, Thewalt JL, Bloom N, Kitson N.
All Rights Reserved. Function of Skin ation (52). Generation and activation of the serine protease, plasmin, from plasminogen is induced by uPA and the activated plasmin instigates localized extracellular proteolysis of cell surface adherent proteins and eventual disruption of the hemidesmosomes. The increasing understanding of the role of cytokines in the maintenance of epidermal homeostasis has stimulated research into the possibility of using such compounds as active principles in cosmetic products (53).
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Dermatological and Transdermal Formulations (Drugs and the Pharmaceutical Sciences) by Kenneth A. Walters