By David R. Crowe, Michael Morgan, Stephen Somach, Kara Trapp
This re-creation of the preferred 2007 unique textual content is totally up-to-date with complete colour, prime quality images and illustrations for simple reference via dermatologists, dermatology citizens, fundamental care and emergency medication physicians. offered in an simply available demeanour, this moment variation discusses greater than forty illnesses which can result in critical clinical effects, together with loss of life. geared up alphabetically and focusing extra seriously on dermatopathology than its predecessor, lethal Dermatologic ailments, moment version encompasses a unmarried scientific picture followed via 3 photomicrographs that aspect the diagnostic good points of every case. also, each one subsection discusses a ailment diagnosis with a present bibliography in a succinct, bulleted demeanour, making this a must have reference for clinicians and pathologists alike.
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Extra info for Deadly Dermatologic Diseases: Clinicopathologic Atlas and Text
4. Di Paulo NC. Recognition of human oncogenic viruses by host pattern-recognition receptors. Front Immunol. 2014;5:353. gov/pubmed/25101093. 5. Hughes MP, Hardee ME, Cornelius LA, Hutchins LF, Becker JC, Gao L. Merkel cell carcinoma: epidemiology, target and therapy. Curr Dermatol Rep. 2014;3(1):46–53. http://www. gov/pmc/articles/PMC3931972/. 6. Moore PS, Chang Y. Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer. 2010;10(12):878–89. gov/ pmc/articles/PMC3718018/#R34.
Acute myelomonocytic and acute monocytic leukemia cells are often CD56 +, CD68 +, CD117 −, and CD 34−. Among lymphoproliferative disorders, TdT and CD10 positivity indicates an immature lymphocyte population, while negativity indicates a mature B- or T-cell leukemia. B-cell ALL is PAX-5+ and CD79a+, while T-cell ALL usually stains positive for CD1a, cytoplasmic CD3, CD4, and CD8 (with CD79a negativity). B-cell CLL usually stain positive for Cd5, CD19, CD20, and CD23, which is negative for cyclin D1.
ISRN Surg. 2013;2013:850797. gov/pmc/articles/PMC3570924/. 24. Miller SJ, et al. Merkel cell carcinoma. J Natl Compr Canc Netw. 2009;7(3):322–32. gov/pubmed/ 19401064/. 25. Tai P. Merkel cell cancer: update on biology and treatment. Curr Opin Oncol. 2008;20(2):196–200. nlm. gov/pubmed/18300770. 26. Cirillo F, Vismarra M, Cafaro I, Martinotti M. Merkel cell carcinoma: a retrospective study on 48 cases and review of literature. J Oncol. 2012;749030:9 pages. nih. gov/pmc/articles/PMC3449125/. , hereditary breast ovarian cancer syndrome BRCA1/2, Muir-Torre) Clinical: Nodule, occasionally ulcerated, scalp most common site; rarely pulsatile in association with metastatic renal cell carcinoma; diffuse cutaneous skin color changes with diffuse cutaneous melanosis; diffuse cyanosis with metastatic carcinoid syndrome Histology: Most commonly adenocarcinoma in the dermis, lymphatic/ vascular permeation, pyramidal orientation, foreign appearance, poor tumor differentiation, no connection with the epithelium IHC repertoire: Cytokeratins 7/20, carcinoembryonic antigen, p63, TTF-1 Staging: Implies widespread metastatic disease Prognosis: Less than 1-year survival in most cases Adverse variables: None (ovarian primary may be associated with slightly better prognosis) Treatment: Surgery, chemotherapy, biologics Cutaneous metastases occur in approximately 10 % of all cancer patients.
Deadly Dermatologic Diseases: Clinicopathologic Atlas and Text by David R. Crowe, Michael Morgan, Stephen Somach, Kara Trapp