Download Current Topics in Developmental Biology by Gerald P. Schatten (Eds.) PDF

By Gerald P. Schatten (Eds.)

ISBN-10: 0123739144

ISBN-13: 9780123739148

This serial presents a accomplished survey of the most important issues within the box of developmental biology. those volumes are necessary to researchers in animal and plant improvement, in addition to to scholars and pros who wish an creation to mobile and molecular mechanisms of improvement. The sequence has lately handed its 30-year mark, making it the longest-running discussion board for modern concerns in developmental biology. quantity eighty offers seven chapters at the newest study in developmental biology.

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ECs have other functions than constituting pipelines for the supply of oxygen. , 1999), as well as for neurogenesis and neural cell fate. , 1992; Zerlin and Goldman, 1997). , 2000). Furthermore, ECs release factors such as BMP‐2, BDNF, and FGF, which 23 1. Angiogenesis and Neurogenesis NSC Neural tube Notch BMP Somite Shh VEGF N Dorsal aorta Notch Axial vein Angioblast Figure 6 Vascular and neural cell fate. Notch expression in the neural tube maintains the NSC potential. When Notch is downregulated NSC start to diVerentiate, then, gradients of morphogens such as Shh, which is secreted by the notochord, and BMP, determine the ventral and dorsal identity of neural progenitors cells and induce distinct neuronal cell subtypes in a dose‐dependent manner along the morphogen gradient.

When Notch signaling is knocked down in zebrafish embryos, there is a loss of artery‐specific markers and an ectopic vein marker‐gene expression in the dorsal aorta. , 2001, 2003). Recent insights have shown that the orphan nuclear receptor, COUP‐ TFII, has a critical role in repressing Notch signaling to maintain vein identity. , 2005). The neurovascular link is further supported by the cell‐fate specification of neural crest (NC) cells. NC cells segregate from the dorsal portion of the neural tube and migrate as a pluripotent cell population to several regions in the embryo.

However, the first evidence that morphogenetic signaling further contributes to growth cone steering originated from studies on FGF signaling on target recognition. a. Fibroblast Growth Factor. FGF proteins constitute a large family of secreted factors composed of at least 23 members, which give rise to a series of splice variants and bind to cell surface tyrosine kinase receptors, encoded by four genes (FGFR1‐4). Several FGFs and at least three receptors are expressed in the developing CNS. , 1996).

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