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By Norton Greenberger, Richard Blumberg, Robert Burakoff

Whole insurance of diagnosing and treating digestive tract and liver problems Edited via the world-renown crew at Brigham and Women's sanatorium of Harvard collage, this new addition to the preferred present sequence offers you all you must recognize for diagnosing and treating digestive tract and liver issues. present prognosis and remedy in Gastroenterology, Hepatology, and Endoscopy  takes an explicitly scientific method offered in a hugely formatted layout. between its such a lot outstanding positive aspects is thorough assurance of endoscopy and liver issues.

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Example text

These studies in humans and animal models of IBD strongly support the hypothesis that CD1d-restricted NKT cells are responsible for the elevated IL-13 observed in UC. IL-13 is a highly inflammatory cytokine that has a strong tendency to disrupt the intestinal epithelial cell barrier, as do TNF and IL-6, which are also increased in UC 18 ᮡ CHAPTER 2 due to the activity of inflamed macrophages and dendritic cells in this disease. Disruption of the epithelial barrier in UC may be due to collateral damage from the deleterious effects of these cytokines (TNF and IL-13).

It may occur even when IBD is quiescent and often does not respond to front-line IBD therapies. Dapsone, thalidomide, calcineurin inhibitors, mycophenolate, and high-dose corticosteroids have been used. Dermatologic referral is suggested. Uveitis is of special concern, as it can lead to blindness if untreated. Patients with eye pain, redness, and visual disturbance require urgent ophthalmologic evaluation. Itzkowitz SH, Present DH; Crohn’s and Colitis Foundation of America Colon Cancer in IBD Study Group.

Forcione DG, Sands BE. Differential diagnosis of inflammatory bowel disease. In: Sartor RB, Sandborn WJ (editors). Inflammatory Bowel Diseases. Saunders, 2004:359–379. ᮣ Complications As previously discussed, Crohn disease frequently causes complications from penetrating and stenosing disease, including perforation, abscess, fistulae, and obstruction. Active small bowel disease or extensive small bowel resection may lead to complications from malabsorption, the severity of which depend on the location and extent of nonfunctioning (or surgically excised) bowel.

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Current Diagnosis and Treatment in Gastroenterology, Hepatology, and Endoscopy by Norton Greenberger, Richard Blumberg, Robert Burakoff


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