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By Dr. Luigi Solbiati, Dr. Alberto Martegani, Dr. Edward Leen, Dr. Jean Michel Correas, Dr. Peter N. Burns, Dr. Dirk Becker (auth.)

ISBN-10: 884702093X

ISBN-13: 9788847020931

ISBN-10: 8847021685

ISBN-13: 9788847021686

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Specific transporters have been identified to facilitate the uptake of hydrophilic bile acids, amino acids, and organic anions such as sulfobromophthalein. All of these transporters rely on the potential difference maintained across the hepatocyte membrane (-35 mY) and the inward sodium concentration gradient. Bile acids also enter hepatocytes by specific transporters located on the sinusoidal plasma membrane. Most studies have supported a sodium-coupled transporter for most of the bile acids found in humans.

In knowledge of the demand for precision and efficacy in medical diagnosis, the lack of contrast agents has left ultrasound in its infancy in many clinical applications. X-ray and magnetic resonance (MR) contrast media are atomic in nature, the fundamental interaction leading to the efficacy of the contrast agent is a physical effect based on the use of atomic properties. The atoms leading to this effect are linked to molecules responsible for the favorable safety and pharmakokinetic properties of the contrast agents.

Echocardiography 16:761-766 Cohen JL, CheirifJ, Segar DS (1998) Improved left ventricular endocardial border delineation and opacification with OPTISON (FS069), a new echocardiographic contrast agent. Results of a phase III Multicenter Trial. J Am Coil CardioI32:746-752 Dittrich HC, Bales GL, Kuvelas T (1995) Myocardial contrast echocardiography in experimental coronary artery occlusion with a new intravenously administered contrast agent. J Am Soc Echocardiogr 8:465-474 Dhond MR, Nguyen TT, Dolan C, Pulido G, Bommer WJ (2000) Ultrasound-enhanced thrombolysis at 20 kHz with air-filled and perfluorocarbon-filled contrast biospheres.

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Contrast-Enhanced Ultrasound of Liver Diseases by Dr. Luigi Solbiati, Dr. Alberto Martegani, Dr. Edward Leen, Dr. Jean Michel Correas, Dr. Peter N. Burns, Dr. Dirk Becker (auth.)


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