By Dwaine F. Emerich, Reginald L. Dean III, Paul R. Sanberg
Alkermes, Inc., Cambridge, MA. Discusses getting older and Alzheimer's illness, advancements in animal versions of Parkinson's sickness and Huntington's illness, advancements for acute neurological stipulations, and advancements in healing brokers. Halftone illustrations. For researchers. DNLM: Alzheimer Disease--physiopathology.
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Independent of the type of memory measuredand its relationship to human deficit (or lack of it), a significant limitation with rodent tasks is that they rarely include suff cient controls to permit one to conclude that the performance deficit is necessaril related to a deficiency in recent memory, per se. An important difference between th majority of rodent tasks used to study age-related memory loss and the nonhuman pri mate task discussed earlier, for example, is the use of several control trials within eac test session under which little or no memory is required.
However, it remains uncertain how suitable they are for modeling the recent, episodic memory losses associated with cholinergic dysfunction in AD patients, as well as those in human and nonhuman primates. Both the water maze and the radial maze tasks have a significant spatial component, requiring that the animal navigate in space to perform the task. Thus, this spatial deficiency places the aged rats at a distinct disadvantage before any requirement of memory is imposed. Attempts to equate for this deficiency have been few and difficult to implement.
5). In other words, bymaking subtle changes in the parameters of the task, it was shifted from one primarily dependent upon recent episodic memory to one requiring other forms of learning and longer term memory. ) Fig. 4. The temporal performance gradient was established by allowing acces to only four of the eight arms before the delay interval (selected by the experimenter and varied from session to session). Following variable delay intervals, all eight arms were available to assess the animals' ability to remember which arms had been visited earlier in the session Delay intervals varied from 15 min to 8 h.
Central Nervous System Diseases by Dwaine F. Emerich, Reginald L. Dean III, Paul R. Sanberg