Download Cell Signaling and Growth Factors in Development: From by Klaus Unsicker, Kerstin Krieglstein PDF

By Klaus Unsicker, Kerstin Krieglstein

ISBN-10: 3527310347

ISBN-13: 9783527310340

This can be the 1st guide based in accordance with organ platforms to hide either embryogenesis and organ improvement. It addresses the capabilities of developmental signaling pathways and development components with a spotlight on mobile department, cellphone migration, and phone differentiation. A uniform article constitution through the booklet enables effortless comparability of knowledge. functions in molecular drugs are highlighted with chapters on developmental problems and similar novel healing options.

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Extra info for Cell Signaling and Growth Factors in Development: From Molecules to Organogenesis

Example text

In the central nervous system (CNS), gene deletion studies have demonstrated that Wnt signaling requires neural progenitor proliferation and hippocampal development [51] and the expansion of dorsal neural cells including the neural crest [52]. Conversely, Wnt signal activation by overexpression of Wnt or of constitutively activated b-catenin impairs neuronal differentiation and increases the progenitor pool, resulting in a massive enlargement of neural tissue in certain areas of the brain [53–55].

Accordingly, differentiation may be initiated when the stem cell leaves the niche. The balance of quiescence, self-renewal, and cell commitment is influenced by secreted growth factors that initiate intracellular signaling cascades and activate distinct sets of transcription factors. Further, the extracellular matrix (ECM) plays an important role in retaining the stem cells in the niche. Thus, self-renewal versus lineage specification and differentiation are the result of the capacity of a stem cell to integrate multiple signals that vary with location and time.

Notch receptors are activated by Deltalike ligands (Dll–1, –3, and –4) and Serrate-like ligands (Jagged–1 and –2) presented by neighboring cells. The signaling pathway is initiated by ligand binding, which induces a proteolytic cleavage of the Notch intracellular domain (NICD). Once released from the plasma membrane, NICD translocates to the nucleus where it binds the transcriptional regulator CSL (CBF1/Suppressor of Hairless/Lag1), DNA-binding proteins [77], and the Mastermind (Mam)/Lag3 co-activator [78].

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Cell Signaling and Growth Factors in Development: From Molecules to Organogenesis by Klaus Unsicker, Kerstin Krieglstein

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