Download Calcium, Oxygen Radicals and Cellular Damage (Society for by C. J. Duncan PDF

By C. J. Duncan

ISBN-10: 0521380685

ISBN-13: 9780521380683

This quantity documents the lawsuits of a gathering held by means of the Society for Experimental Biology that tried to figure out no matter if there are universal mechanisms of mobile harm and to discover the ways that calcium and oxygen radicals may possibly engage to generate the wear.

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Extra resources for Calcium, Oxygen Radicals and Cellular Damage (Society for Experimental Biology Seminar Series)

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Science 233, 853-9. S. M. (1985). Enhancement by adriamycin of the effect of 12-o-tetradecanoylphorbol-13acetate on mouse epidermal glutathione peroxidase activity, ornithine decarboxylase induction and skin tumor promotion. Cancer Letters 29, 127-37. , Chaponnier, C , Jeanrenaud, B. & Gabbiani, G. (1979). Actin microfllaments, cell shape, and secretory processes in isolated rat hepatocytes: effect of phalloidin and cytochalasin D. Journal of Cell Biology 81, 592-607. Sies, H. ) (1985). Oxidative stress: introductory remarks.

1988). Active oxygeninduced DNA strand breakage and poly-ADP-ribosylation in promotable and non-promotable JB6 mouse epidermal cells. Carcinogenesis 9, 239-45. Murachi, T. (1983). Intracellular Ca2+ proteases and its inhibitor protein: calpain and calpastatin. In Calcium and Cell Function vol. IV, ed. Y. Cheung, pp. 376-^10. Orlando, Fl: Academic Press. , Davis, G. & Orrenius, S. (1986). The formation of plasma membrane blebs in hepatocytes exposed to agents that increase cytosolic Ca2+ is mediated by the activation of a nonlysosomal proteolytic system.

NADPH is believed to be the substrate in vivo and this is provided by the increased activity of the hexose monophosphate shunt which accompanies cell stimulation. The NADPH oxidase is, in fact, a multicomponent enzyme complex which constitutes an electron transfer chain from NADPH and terminates in O2 reduction. Thus, the overall reaction catalysed by the oxidase is: NADPH + 2O2 -> 2CV + NADP+ + H + (1) Regulation of neutrophil oxidant production 37 The O 2 " generated may then dismutate either enzymically or spontaneously: 2CV + 2H + -> O 2 + H 2 O 2 (2) Further reactions of O2~ and H 2 O 2 are possible and in the presence of transition metal salts such as iron and copper salts, a complex series of redox reaction may occur, summarised as a metal-catalysed Haber-Weiss type reaction (Halliwell & Gutteridge, 1984; 1985): ( V + H2 O 2 -> OH + "OH + O2 (3) The OH which may be formed in this reaction is one of the most reactive species known in biological systems.

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Calcium, Oxygen Radicals and Cellular Damage (Society for Experimental Biology Seminar Series) by C. J. Duncan


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