By E. Sapey
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Additional info for Bronchial Asthma - Emerging Therapeutic Strategies
The analysis of exhaled breath condensate (EBC) is a relatively novel method with a good potential to become the preferred and completely non-invasive alternative to the currently practiced invasive and semi-invasive diagnostic methods for bronchial asthma. New approaches are based on attempting to identify robust biomarkers which could be utilized in establishing the diagnosis of asthma. The former studies investigated the predictive value of EBC pH for asthma, the latter chose to research hydrogen peroxide, nitrogen oxides, arachidonic acid derivatives, cytokines and others.
The doubling concentrations of AMP are delivered to the participant via nebulizer for 2 minutes with spirometric measurement every two minutes until a 20% fall in FEV1 is recorded. AMP may provide a good demonstration of airway inflammation based on sputum eosinophils. AMP is cheap and may be a good way to monitor inflammation. It can also cause sputum eosinophilia within 1 hour of the challenge. An inflammatory response after the AMP challenge could present a problem and needs to be considered before using the AMP challenge as a diagnostic tool.
R. (1985) Eucapnic voluntary hyperventilation of compressed air mixture. A simple system for bronchial challenge by respiratory heat loss. Am Rev Respir Dis 131(1):31-135) Riedler J, Reade T, Dalton M, Holst D, et al. (1994) Hypertonic saline challenge in an epidemiologic survey of asthma in children. Am J Respir Crit Care Med. 150:1632-9. , Slee, J. (2008) Exercise and other indirect challenges to demonstrate asthma or exercise-induced bronchoconstriction in athletes . , et al. (1981) Standardization of inhalation provocation tests: two techniques of aerosol generation and inhalation compared.
Bronchial Asthma - Emerging Therapeutic Strategies by E. Sapey