By Jamie Davies
Branching morphogenesis, the production of branched constructions within the physique, is a key function of animal and plant improvement. This publication brings jointly, for the 1st time, specialist researchers engaged on various branching platforms to offer a cutting-edge view of the mechanisms that keep an eye on branching morphogenesis. platforms thought of variety from unmarried cells, to blood vessel and drainage duct structures to complete physique plans, and ways diversity from statement via test to unique biophysical modelling. the result's an built-in evaluation of branching.
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Additional info for Branching Morphogenesis (Molecular Biology Intelligence Unit)
Indeed, Kalil and colleagues suggest that axon guidance and interstitial branch formation might be similarly regulated by chemotropic molecules that modulate growth cone dynamics,^ implicating these molecules in a variety of morphological pathways necessary for establishing fiinctional neuronal circuits. Ephtins Ephrins comprise a family of multifiinctional chemotropic signaling molecules, some of which serve critical roles in establishing appropriate topographic patterning of retinotectal connections during visual system development.
279,288 p^j. "^^^'"^^^'"^^^ In combination, these recent studies demonstrate that ephrins serve numerous roles during neuronal morphogenesis, collectively regulating axonal or dendritic outgrowth, fasciculation, and arborization. Semaphorins Semaphorins constitute a large family of secreted and transmembrane proteins variously involved in growth cone collapse (CoUapsin-l/Semaphorin IIIA ^), axon guidance through chemorepulsion (CoUapsin-l/Semaphorin IIIA, HID '•^^^), stimulation or inhibition of axonal arborization (Semaphorin IILA85-87,29 ^^ ^j^j neuronal apoptosis (Semaphorin IIIA^^^).
For example, in the developing visual system, ocular dominance columns are established and maintained through the segregation of eye-specific afferent inputs that are characterized by distinct patterns of electrical activity. ^ ^ ' B e c a u s e specific activity patterns also have been found to direct selective pruning of dendritic arbors, neuronal activity is thought to regulate the overall degree and rate of dendritic branch additions and retractions as \ r ' IS ^8 12S 144 neurons mature and rorm synaptic contacts.
Branching Morphogenesis (Molecular Biology Intelligence Unit) by Jamie Davies