By Karl Schügerl
This quantity covers tracking of the biotechnological strategy with refined analytical recommendations, use of the ensuing facts through mathematical versions, and computer-aided keep an eye on for development of the productiveness of biotechnological strategies. The ebook includes 4 major elements: tools for research and biosensoring, measuring options, technique types and their automation and keep an eye on. using diverse telephone forms, recombinant microorganisms, and reactor stipulations are provided and all current thoughts of tracking and optimizing phone development and product formation are mentioned with reference to greater productiveness. issues integrated are: equipment and tools/ Biosensors/ Characterization of Bioreactors/ decision of mobilephone focus/ mobilephone versions/ Stirred Tank types/ Tower Reactor versions/ procedure types/ keep watch over of Bioreactor structures/ Automation/ keep watch over of Downstream Processing
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Extra info for Biotechnology, 2nd Edition, Volume 4: Measuring, Modelling and Control
1 Objectives of On-Line Gas Analysis and Requirements for Accuracy and Reliability Three different levels of complexity using the results of gas analysis may be identified: In industrial practice it is often of paramount importance to guarantee and prove the exact repeatability of batches.
PP. 182-220. New York: John Wiley & Sons. FAN, L. , WAN, C. G. (19631, An application of the discrete maximum principle to a stagewise biochemical reactor system, Biotechnol. Bioeng. 5 , 201-209. FLYNN,D. S. (1982), Instrumentation for fermentation processes, in: Modelling and Control ofBio- ' 24 I Common Instruments fo r Process Anal)wis and Control technological Processes, pp. 5-12. Helsinki: IFAC. FORAGE,D. , HARRISON,D. E. , PITT, D. E. (1985), Effect of environment on microbial activity, in: Comprehensive Biotechnology (BULL,A.
The exact form of the response curve depends on KLa, the Cf, - CL, driving force, and the dynamics of the measurement. The liquid balance gives: The classical dynamic KLa method assumes that KLa and CLl are constant. Then the differential equation can be integrated analytically to yield: (37) 35 Lnll-CI Time tl t2 t 3 Fig. 3. Approximate method to determine KLa (RUCHTIet al.. 1985). Usually deoxygenation is accomplished with nitrogen so that the initial gas phase consists of nitrogen, which is gradually displaced and mixed with air.
Biotechnology, 2nd Edition, Volume 4: Measuring, Modelling and Control by Karl Schügerl