Download Biomedical nanomaterials by Yuliang Zhao, Youqing Shen PDF

By Yuliang Zhao, Youqing Shen

ISBN-10: 3527694390

ISBN-13: 9783527694396

ISBN-10: 3527694439

ISBN-13: 9783527694433

The e-book discusses in a close demeanour quite a few nanomaterials used for biomedical purposes, together with scientific functions, prognosis and tissue engineering. After the presentation of an summary of biomedical nanomaterials, together with their type and purposes, the 1st a part of the ebook is dedicated to biomedical nanomaterials for treatment functions. for instance, polymer micelles, dendrimers, Read more...

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The ebook discusses in a close demeanour numerous nanomaterials used for biomedical purposes, together with medical purposes, analysis and tissue engineering. Read more...

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4 PK data of drug-loaded synthetic NMs. , 10 IU kg−1 , rats. , 10 IU kg−1 , rats. , 10 IU kg−1 , rats. , 10 mg kg−1 , Mice. 10) Pulmonary absorption, rats. 2-fold) Pulmonary absorption, rats. 1% w/v PAMAM Peg5k-dendritic lysine-cholic acid (PEG5k-CA8) + paclitaxel Peg5k-dendritic lysine-cholic acid (PEG5k-CA8) + daunorubicin; nontargeted dendrimer CLL1-Peg5k-dendritic lysine-cholic acid (PEG5k-CA8) + daunorubicin; targeted dendrimer, 14 nm Peg5k-dendritic lysine-cholic acid (PEG5k-CA8) + daunorubicin; nontargeted dendrimer CLL1-Peg5k-dendritic lysine-cholic acid (PEG5k-CA8) + daunorubicin; targeted dendrimer, 14 nm Description Pulmonary absorption, rats.

For example, the blood clearance rate (CL) and mean resident time (MRT) of Dox [121] and curcumin [122] in the nanoformulations were greatly extended with PEGylation. Surfactant coating was also effective in adjusting the surface characteristics of NMs, and thus changed blood PK of the drugs [129]. 5. Ligand modification. Generally, ligand modification promotes preferential uptake by the target organ. In order to increase the targeting efficiency for indomethacin delivery, PAMAMs modified with different amounts of folic acid were investigated.

4–200 nm revealed that the liver remained the most preferential target of the injected NMs [146]. 15). 5. 1. Long-chain PEGs are more effective than their short-chains counterparts to create dense surface polymer coating [145]. Besides, the brush- and mushroom-like PEG confirmations are the most effective forms in protecting NMs from rapid clearance [98]. 2. ” Uptake by the RES organ becomes the major clearance route for the large NMs. 2 PK Differences Between Drugs Encapsulated by Different NMs PK analysis of different formulations for a certain drug enables the selection of the suitable NMs for efficient delivery.

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Biomedical nanomaterials by Yuliang Zhao, Youqing Shen


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