By Homare Tabata (auth.), Jian-Jiang Zhong (eds.)
Advances in bioproducts production similar to the construction of the anticancer drug paclitaxel by means of large-scale plant telephone tradition, submerged cultivation of medicinal mushrooms, and monoclonal antibody construction are mirrored. Interactions between molecular, mobile and procedure engineering features in commercial fermentations are mentioned, and alertness of fuzzy keep watch over and fuzzy neural networks to useful creation and the biomedical quarter are proven. For sustainable improvement and eco-friendly processing, creation of lactic acid from paper sludge, construction of a widely used fermentation feedstock from wheat, and fabrication and alertness of whole-cell dependent biosensors within the setting also are demonstrated.
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Krast (Polyporaceae) is one of the most famous traditional Chinese medicinal herbs. It has been a popular folk and an oriental medicine used to treat many diseases, for example, hepatitis, hypertension, hypercholesterolemia, and gastric cancer [30, 31]. Studies on this mushroom have revealed many interesting biological activities, including antitumor activity [32, 33] and hypoglycemic activity of its polysaccharides (including ganoderans) [31, 34, 35]. The intracellular polysaccharides isolated from fruiting body and the mycelium culture of G.
Chinensis T. canadensis T. 1      tion of paclitaxel in the white precipitate is approximately 30 to 50%. To increase the recovery rate, paclitaxel should be extracted both from the white precipitate and from the cells. The steady high productivity of paclitaxel is important for commercial purposes. The stability of paclitaxel production under these conditions was studied (Fig. 13). Repeating the cultivation 18 times resulted in stable production of paclitaxel in the range 140 to 295 mg L–1.
Lucidum in stirred bioreactors. Symbols: empty symbols, batch culture; filled symbols, fed-batch culture; triangles, a-PGM activity; circles, EPS concentration. -J. Zhong · Y-J. Tang Our work showed the positive response of a-PGM activity and EPS accumulation by G. lucidum to sugar feeding. The results suggest there might be a correlation between a-PGM activity and EPS biosynthesis by G. lucidum, and lactose addition might be useful in regulating cell metabolism and physiology in bioreactors. With regard to the responses of PGI activity and lactate accumulation to lactose feeding, the PGI activity in fed-batch culture was lower than in batch culture; this was also true for lactate concentration .
Biomanufacturing by Homare Tabata (auth.), Jian-Jiang Zhong (eds.)