By Matt Kalaycio
The Cleveland hospital starting place, OH. textual content covers information regarding new biologic cures and gives the medical professional with sensible info for treating sufferers with leukemia. Discusses such remedies as arsenic trioxide, P-glycoprotein inhibitors, and interleukins. additionally covers genetic code adjustments. DNLM: Leukemia, remedy.
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Extra resources for Biologic Therapy of Leukemia
Incidence of mixed chimerism using busulfan/cyclophosphamide containing regimens in allogeneic gone marrow transplantation. Bone Marrow Trans 1992;9:293–297. 42. Ely P, Miller W. bcr/abl mRNA detection following bone marrow transplantation for chronic myelogenous leukemia. Transplantation 1991;52:1023–1028. 43. Miyamura K, Tahara T, Tanimoto M, et al. Long persistent bcr-abl positive transcript detected by polymerase chain reaction after marrow transplant for chronic myelogenous leukemia without clinical relapse: a study of 64 patients.
Furthermore, rituximab’s excellent tolerability profile makes it an ideal agent with which to investigate combination therapies. Indeed, preliminary results of two clinical trials that combine fludarabine, cyclophosphamide, and rituximab for patients with B-CLL have recently been reported. In the first study, 43 patients with previously treated B-CLL were treated first with rituximab 375 mg/m2 on day 1, followed by fludarabine 25 mg/m2 and cyclophosphamide 250 mg/m2 on days 2 through 4 (30). The dose of rituximab was increased to 500 mg/m2, and chemotherapy was started on day 1 for the subsequent five cycles of treatment.
Of interest, the median response duration had not been reached with short follow-up, even for patients who only achieved a partial remission. Whether administered subcutaneously or intravenously, the first dose of alemtuzumab caused fevers and rigors and one patient experienced a CMV infection. Several other preliminary studies suggest high remission rates in previously untreated patients, but larger randomized trials are needed to confirm any purported survival advantage compared with currently available standard therapies (54,55).
Biologic Therapy of Leukemia by Matt Kalaycio