Download Bioinformatics: Volume II: Structure, Function, and by Jonathan M. Keith PDF

By Jonathan M. Keith

ISBN-10: 1493966111

ISBN-13: 9781493966110

ISBN-10: 1493966138

ISBN-13: 9781493966134

This moment version presents up to date and extended chapters masking a vast sampling of precious and present equipment within the quickly constructing and increasing box of bioinformatics. Bioinformatics, quantity II: constitution, functionality, and functions, moment version is made from 3 sections: constitution, functionality, Pathways and Networks; functions; and Computational tools. the 1st part examines methodologies for figuring out organic molecules as structures of interacting parts. The purposes part covers a variety of purposes of bioinformatics, concentrating on research of genome-wide organization facts, computational diagnostic, and drug discovery. the ultimate part describes 4 commonly appropriate computational tools which are very important to this box. those are: modeling and inference, clustering, parameterized algorithmics, and visualization. As a quantity within the hugely profitable Methods in Molecular Biology series, chapters function the type of element and specialist implementation recommendation to make sure confident results.

Comprehensive and useful, Bioinformatics, quantity II: constitution, functionality, and Applications is a necessary source for graduate scholars, early profession researchers, and others who're within the strategy of integrating new bioinformatics equipment into their research.

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Extra resources for Bioinformatics: Volume II: Structure, Function, and Applications

Example text

The possibility of adjacently conserved paralogs, genes that diverge after duplication events [21], was also discussed by Overbeek et al. [3]. Moreover, other work has shown that operons have a tendency toward producing paralog operons [14, 25], and that strict detection of orthologs is not necessary for prediction of functional association [14]. Thus, here I use conservation of unidirectional best hits for predicting interactions by conservation of gene order. ” The ‘-outfmt 6’ option instructs BLASTP to format the results into a simple, tab-separated, table.

Letunic I, Doerks T, Bork P (2012) SMART 7: recent updates to the protein domain annotation resource. Nucleic Acids Res 40(Database issue):D302–D305 23. Schultz J, Milpetz F, Bork P, Ponting CP (1998) SMART, a simple modular architecture research tool: identification of signaling domains. Proc Natl Acad Sci U S A 95 (11):5857–5864 24. Pearson WR, Lipman DJ (1988) Improved tools for biological sequence comparison. Proc Natl Acad Sci U S A 85(8):2444–2448 25. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool.

J Mol Biol 416:668–677 36. Yagi H, Pilla KB, Maleckis A, Graham B, Huber T, Otting G (2013) Three-dimensional protein fold determination from backbone amide pseudocontact shifts generated by lanthanide tags at multiple sites. Structure 21:883–890 37. Liepinsh E, Baryshev M, Sharipo A, IngelmanSundberg M, Otting G, Mkrtchian S (2001) Thioredoxin fold as homodimerization module in the putative chaperone ERp29: NMR structures of the domains and experimental model of the 51 kDa dimer. Structure 9:457–471 38.

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Bioinformatics: Volume II: Structure, Function, and Applications by Jonathan M. Keith

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