By Wilhelm, Klaus-Peter
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Additional info for Bioengineering of the Skin: Skin Imaging & Analysis
Probably the most common form of scaling is seen in ordinary dry skin (xerosis vulgaris, winter xerosis), which is especially prevalent on the lower legs. Scaling can mask the glyphic patterns; these become visible again after a few tape strippings. Fine scales often originate in the lines. Figure 9 shows the development of scaling on the lateral lower leg, induced by a 5% sodium lauryl sulfate patch applied for 24 hours. The picture was taken seven days after the removal of the patch. Fine cracks form within the primary glyphic lines, which have reappeared.
Low temperatures and humidities result in rapid worsening; by contrast, wetness immediately masks scaling. Attempts have been made to measure xerosis using indirect methods such as electrical conductance, on the assumption that the desquamating portion of the stratum corneum lacks water (35–38). However, here too, changes in humidity yield false values. Another approach has been to obtain silicon replicas from scaly skin and determine so-called roughness parameters of the surface using laserprofilometry (19,20,22).
Krazy Glue1) is applied on a transparent plastic slide and pressed onto the skin. After a few minutes, the slide is carefully pulled off. A sheet of the outermost horny layer is separated to which vellus hairs are attached. The density and size of the openings of follicles can be determined. In silicon replica casts, only the follicular orifices can be studied. The density of follicles has received little attention in the literature. , the leg with about 50/cm2 (44). In the face, the density of follicles decreases from centrofacial (alae nasi and nose: 1200/cm2; to lateral preauricular: 460 cm2) (42).
Bioengineering of the Skin: Skin Imaging & Analysis by Wilhelm, Klaus-Peter