By Reshma Taneja
This new quantity of Current themes in Developmental Biology offers a entire set of reports on bHLH transcription factors. bHLH components are greatly well-known for his or her different roles in developmental techniques and their disorder underlies numerous human pathologies. every one bankruptcy is authoritatively written by way of a number one specialist within the box and discusses each attainable point of this massive and various field.
- Covers the world of easy helix-loop-helix (bHLH) transcription elements in improvement and disease
- International board of authors
- Provides a accomplished set of reports on our present figuring out at the functionality of bHLH elements in improvement of assorted tissues and the way de-regulation of those elements may cause, or is associated with, numerous human diseases
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Extra resources for BHLH transcription factors in development and disease
2013), it will be important to obtain genome-wide maps during myogenic specification of ES and iPS cells. , 2010; Watt & Huck, 2013). Therefore, the evaluation of these parameters for myogenic differentiation of human ES or iPS cells will allow the expansion of more homogenous self-renewable populations of upstream myogenic stem/progenitors enabling future cell-based therapies for muscle-wasting diseases. Molecular and Cellular Regulation 33 5. 1. , 1994). , 1997; Di Padova, Caretti, Zhao, Hoffman, & Sartorelli, 2007).
2005). , 1997), reviewed in Guasconi & Puri, 2009; Albini and Puri, 2010). The SWI/SNF complexes act in virtually all cell processes, and they are essential for establishing and maintaining pluripotent and multipotent cell states (Lessard & Crabtree, 2010). In addition to the ATPase subunit (BRG1 or BRM), SWI/SNF complexes are composed of 10 other nonenzymatic structural subunits (BAFs), which are assembled in different combinations from 20 different gene products. This combinatorial can potentially yield hundreds of complexes with different functions in a variety of cell types 36 Glenda Comai and Shahragim Tajbakhsh (Wu, Lessard, & Crabtree, 2009; Puri and Mercola, 2012).
Inadequate expression of the Cre/reporter combination might explain some of these discrepancies. In conclusion, lineage tracing and ablation studies are commonly used tools to reveal the lineage relationships between progenitors and their descendants within a tissue. However, for proper interpretation of results, one must ensure that: (i) Cre expression faithfully follows that of the endogenous gene, (ii) the reporter line is responsive in the tissue of interest, and (iii) the reporter line reflects the full spectrum of Cre and endogenous gene expression.
BHLH transcription factors in development and disease by Reshma Taneja