By Christos C. Zouboulis
Dermatological examine has skilled a speedy improvement within the final twenty years, even though, it has infrequently excited by the endocrine services of the surface. just a couple of years in the past clinicians and researchers in dermatology began to discover the surface as a goal organ for many hormones. within the final years the surface has been famous because the biggest endocrine, paracrine and autocrine organ of the physique. it could metabolize steroid hormones and to supply derivatives with probably systemic task. issues of hormone metabolism can both set off direct results at the epidermis or not directly disturb dermis homeostasis. Endocrine dermatology is a brand new and fascinating quarter of dermis learn. It comprises dermis illnesses because of or linked to endocrine issues, pores and skin issues that are taken care of with hormones or with compounds with hormone-like task, and dermis issues which take place as hostile occasions of hormone remedy or of remedy with compounds displaying a hormone-like influence.
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Extra resources for Basic Research in Endocrine Dermatology: 3rd Teupitzer Colloquium, Berlin, September 17-20, 2000 (Special Issue: Hormone Research 2000, 5-6)
6 Hamilton JB: Age, sex and genetic factors in the regulation of hair growth in man: A comparison of Caucasian and Japanese populations; in Montagna W, Ellis RA (eds): The Biology of Hair Growth. New York, Academic Press, 1958, pp 399–433. 7 Randall VA: Androgens: The main regulator of human hair growth; in Camacho FM, Randall VA, Price VH (eds): Hair and Its Disorders: Biology, Pathology and Management. London, Martin Dunitz, 2000, pp 69–82. 8 Hamilton JB: A secondary sexual character that develops in men but not in women upon ageing of an organ present in both sexes.
Jenner a Isobel De Oliveira a Andrew G. Messenger d a Department of Biomedical Sciences, University of Bradford, UK, b now at Kanebo Cosmetics Laboratory, Odawara City, Japan, c now at Department of Dermatology, University of Tokushima, Japan, d Department of Dermatology, Royal Hallamshire Hospital, Sheffield, UK Key Words Balding W Beard W Dermal papilla cells W Growth factors W Hair follicle W Human W Stem cell factor Abstract Androgens are the main regulator of normal human hair growth. g. the axilla.
22 Van Scott EJ, Ekel TM: Geometric relationships between the matrix of the hair bulb and its dermal papilla in normal and alopecic scalp. J Invest Dermatol 1958;31:281–287. 23 Elliot K, Stephenson TJ, Messenger AG: Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number: Implications for the control of hair follicle size and androgen responses. J Invest Dermatol 1999;113:873–877. 24 Randall VA, Hibberts NA, Thornton MJ, Merrick AE, Hamada K, Kato S, Jenner TJ, De Oliveira I, Messenger AG: Do androgens influence hair growth by altering the paracrine factors secreted by dermal papilla cells?
Basic Research in Endocrine Dermatology: 3rd Teupitzer Colloquium, Berlin, September 17-20, 2000 (Special Issue: Hormone Research 2000, 5-6) by Christos C. Zouboulis