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By Prof. Dr. W. Hort (auth.), Prof. Dr. H. Just, Prof. Dr. W. Hort, PD Dr. A. M. Zeiher (eds.)

ISBN-10: 3642856608

ISBN-13: 9783642856600

ISBN-10: 3642856624

ISBN-13: 9783642856624

A gigantic literature has been excited by arteriosclerosis and but, many points of pathogenesis and of the mechanism of improvement of the arteriosclerotic vascular lesion stay in basic terms poorly understood. in recent times, our wisdom of the earliest levels of arteriosclerosis have tremendously superior. via now, we have now discovered to narrate morphologic alterations to disturbances in functionality. it's been of specific impor­ tance that parts of the arterial wall may be analyzed in regard to disorder, for instance, within the endothelium or the vascular soft muscle. The interplay of the several morphological elements of the vascular wall may possibly therefore be a lot wager­ ter understood. Likewise, the interplay among the arterial wall and the flowing blood might be far better defined, together with the intimate dating among platelets and the endothelium, the coagulation approach and the endothelium, the granulocytes and the endothelial mobilephone layer, in addition to techniques of migration of blood cells into the subendothelial house. the popularity of useful and morphological disturbance has attained medical value not just as the arteriosclerotic illnesses have quantitatively reached the scale of a plague, that's, of a significance by no means been witnessed. it's also as a result improvement of latest medicines that intervene with the atherogenic strategy and thereby hinder the advance of the disorder or halt its development. it's also changing into more and more attainable to inhibit the incidence of problems in latest arteriosclerotic lesions in occur ailment, i. e.

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Additional info for Arteriosclerosis: New Insights into Pathogenetic Mechanisms and Prevention

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Are there specific immune responses in atherosclerosis? Immunohistochemical studies show that a substantial proportion of the macrophages and T lymphocytes in the atherosclerotic plaque are activated, and this suggests that they might react with specific antigens in the tissue. Such antigens have, however, not yet been identified and it is now important to determine whether this type of immune responses take place in atherogenesis. Circumstantial evidence suggest that specific immune responses may be elicited against oxidation epitopes on lipoproteins.

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SpringerVerlag, Berlin, pp. 27-38 18. McMillan GC (1985) Nature and definitions of atherosclerosis. In: Lee, KT (ed) Atherosclerosis. Ann NY Acad Sci 454: 1-4 19. Mitchell JRA, Schwartz CJ (1965) Arterial disease. F. A. Davis Co, Philadelphia 20. M~ller L, Kristensen TS (1991) Plasma fibrinogen and ischemic heart disease risk factors. Arteriosclerosis and Thrombosis 11: 344-350 21. Munro JM, Van derWalt JD, Munro CS, Chalmers JAC, Cox EL (1987) An immunohistochemical analysis of human aortic fatty streaks.

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Arteriosclerosis: New Insights into Pathogenetic Mechanisms and Prevention by Prof. Dr. W. Hort (auth.), Prof. Dr. H. Just, Prof. Dr. W. Hort, PD Dr. A. M. Zeiher (eds.)


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