By Robert Lev
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the giant physique of easy technological know-how and scientific info linked to adenomatous polyps of the colon, a lot of it encouraged via the conclusion that almost all colorectal carcinomas appear to come up in such polyps. This booklet strives to guage those info, with specific emphasis on their implications for administration of polyp-bearing matters. subject matters comprehensively explored contain anatomy and histology of the traditional colon; pathologic features of adenomatous polyps, differential analysis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic facts for the malignant capability of adenomatous polyps; and detection and administration, with designated recognition to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.
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Extra info for Adenomatous Polyps of the Colon: Pathobiological and Clinical Features
3 summarizes a recent review by Spratt and Spratt (1985) that shows doubling times from four earlier studies, including the Welin work cited above. 3. Mean doubling times for adenomatous polyps, carcinomas, and metastases. Polyps Carcinomas Metastases n Arithmetic mean (days) Range (days) 77 1,600 668 221 13-8,664 52-10,000 98 23 32-3,300 SOURCE: Modified from Spratt and Spratt, 1985. '. (Chaps. B). 8. Regression of Polyps Occasional patients with familial polyposis exhibit regression of rectal adenomas or absence of new lesions after total colectomy and ileoproctostomy (Cole & Holden, 1959).
Boland CR, Montgomery CK, Kim YS (1982) Alterations in human colonic mucin occurring with cellular differentiation and malignant transformation. Proc Nat! Acad Sci USA 79:2051-2055. Brown UR, Smeeton NC, Dixon MF (1985) Assessment of dysplasia in colorectal adenomas: An observer variation and morphometric study. J Clin PathoI38:174-179. Buset M, Lipkin M, Winawer S, Swaroop S, Friedman E (1986) Calcium, cellular proliferation and cancer. Cancer Res 46:5426-5430. Bussey H (1975) Familial Polyposis Coli.
3. Hamartomatous Polyps Various hamartomatous conditions may involve the colon, but only the most common of these, the Peutz-Jeghers syndrome, will be discussed here. This disease, which is transmitted as an autosomal dominant, is characterized by hamartomatous polyps of the gastrointestinal tract, mucocutaneous pigmentation, and a variety of extraintestinal disorders (Dormandy, 1957). The polyps predominate in the small intestine but may also be found in the colon. They consist of irregular aggregates of nonneoplastic glands separated by smooth muscle bundles.
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features by Robert Lev